{"id":9372,"date":"2022-09-08T10:32:15","date_gmt":"2022-09-08T07:32:15","guid":{"rendered":"https:\/\/city-lab.fi\/?p=9372"},"modified":"2022-09-14T16:57:35","modified_gmt":"2022-09-14T13:57:35","slug":"epigenetic-tools-for-disease-research","status":"publish","type":"post","link":"https:\/\/city-lab.fi\/en\/epigenetic-tools-for-disease-research\/","title":{"rendered":"Epigenetic tools for disease research"},"content":{"rendered":"

Labnet’s guest blog<\/em><\/p>\n

As more and more diseases are linked to epigenetic abnormalities, there has been an exponential growth in research focused on the association between epigenetics and disease<\/strong>. As such, laboratories new to the areas of epigenetics and gene regulation research are experiencing a growing need for tools to facilitate the innovation of research into these areas.<\/p>\n

Active Motif<\/strong> is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. Their staff of highly qualified scientists work in close collaboration with world-class researchers to continually develop new and innovative tools to study chromatin, histones, DNA methylation, non-coding RNAs and transcription biology<\/strong>.<\/p>\n

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Epigenetics and disease<\/strong><\/p>\n

The epigenetics state of the cell is controlled by the activity of proteins that add and remove small chemical modifications to histones and to DNA. Aberrant epigenetic regulation can lead to changes in gene expression and human disease (table 1 & 2).<\/p>\n

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The link between epigenetics and disease has been substantiated through the identification of mutations in, or altered expression of, epigenetic regulator proteins that are associated with a multitude of pathological states and poor disease prognosis.<\/p>\n

These mutations have been identified in all three major classes of epigenetic proteins: the Writers (enzymes that deposit modifications), the Erasers (enzymes that remove modifications) and the Readers (proteins that recognize and bind epigenetic modifications). Recent drug development strategies that target these enzymes have proved highly successful, resulting in four FDA approved cancer drugs, with many more promising leads on the horizon.<\/p>\n

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The epigenetic tool kit<\/strong><\/p>\n

The development of methods to perform chromatin immunoprecipitation (ChIP) and analyses of DNA methylation, histones and gene regulation, along with Next-Generation sequencing tools, is allowing researchers to get a better picture of the genome-wide changes associated with cancer and other diseases. Active Motif provides products that utilize familiar techniques and reagents, or simplify technologies, to enable even a novice to perform epigenetic studies. These include:<\/p>\n